Polygonatum rhizoma polysaccharide (PP) is a main ingredient of Polygonatum rhizoma,
which is both food and traditional herbal medicine. In this study, we aimed to investigate the …

Abstract Type 2 diabetes (T2D) is a chronic, burdensome disease that is characterized by
disordered insulin sensitivity and disturbed glucose/lipid homeostasis. Berberine (BBR) has …

Recent studies have shown that, compared with healthy individuals, patients with type 2
diabetes (T2D) suffer a higher severity and mortality of COVID-19. When infected with this …

Increased Nogo-B receptor (NGBR) expression in the liver improves insulin sensitivity by
reducing endoplasmic reticulum stress (ER stress) and activating the AMPK pathway …

NUS1 encodes the Nogo-B receptor, a critical regulator for unfolded protein reaction (UPR)
signaling. Although several loss-of-function variants of NUS1 have been identified in …

The efficacy of berberine in managing diabetes through modulation of gut microbiome has
been established through fecal sample analyses. However, relying solely on fecal materials …

Drug resistance is always a challenge in conquering breast cancer clinically. Recognition of
drug resistance and enhancing the sensitivity of the tumor to chemotherapy is urgent …

Obesity-linked fatty liver is a significant risk factor for hepatocellular carcinoma (HCC) 1, 2;
however, the molecular mechanisms underlying the transition from non-alcoholic fatty liver …

Obesity is a risk factor for insulin resistance, type 2 diabetes, and cardiovascular diseases.
Reticulon-4 (Nogo) is an endoplasmic reticulum–resident protein with unclear functions in …

Background: Hyperlipidemia (hypercholesterolemia and/or hypertriglyceridemia) is a risk
factor for atherosclerosis. Nogo-B receptor (NgBR) plays important roles in hepatic steatosis …