Epilepsy: key experimental therapeutics in early clinical development

C Steriade, J French, O Devinsky - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Antiseizure medications are the mainstay of epilepsy treatment. Currently
therapies are not specific to epilepsy etiology, and control seizures in two-thirds of cases …

Cannabidiol and neurodevelopmental disorders in children

KA Kwan Cheung, MD Mitchell, HS Heussler - Frontiers in Psychiatry, 2021 - frontiersin.org
Neurodevelopmental and neuropsychiatric disorders (such as autism spectrum disorder)
have broad health implications for children, with no definitive cure for the vast majority of …

Transporter Hypothesis in Pharmacoresistant Epilepsies: Is it at the Central or Peripheral Level?

L Czornyj, J Auzmendi, A Lazarowski - Pharmacoresistance in Epilepsy …, 2023 - Springer
The multidrug resistance (MDR) phenotype characterizes patients with refractory epilepsy
(RE). Seizures are not controlled despite receiving various combinations of more than two …

Attitudes toward legalization of marijuana in the United States, 1986-2016: Changes in determinants of public opinion

BE Denham - International Journal of Drug Policy, 2019 - Elsevier
Background Based on recent research in political science, which has conceptualized
political party affiliation as a form of social identity, the present study examined political …

Drug–drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program

TE Gaston, EM Bebin, GR Cutter, SB Ampah, Y Liu… - Epilepsy & behavior, 2019 - Elsevier
Objective We have previously shown that cannabidiol (CBD; Epidiolex®) significantly affects
levels of clobazam/N-desmethylclobazam, rufinamide, topiramate, zonisamide, and …

Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients

L Treat, KE Chapman, KL Colborn, KG Knupp - Epilepsia, 2017 - Wiley Online Library
Objective Oral cannabis extracts (OCE s) are being used in the treatment of epilepsy with
increasing rates in the United States following product legalization; however, no studies …

Recent advances in status epilepticus

E Trinka, F Brigo, S Shorvon - Current opinion in neurology, 2016 - journals.lww.com
Recent advances in status epilepticus : Current Opinion in Neurology Recent advances in
status epilepticus : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …

Cognitive and behavioral effects of cannabidiol in patients with treatment-resistant epilepsy

B Metternich, K Wagner, MJ Geiger, M Hirsch… - Epilepsy & Behavior, 2021 - Elsevier
Purpose Therapeutic use of cannabidiol (CBD) in intractable epilepsies has increased
considerably over the last ten years. As more evidence for the potentially beneficial effects of …

Development of a new method for the analysis of cannabinoids in honey by means of high-performance liquid chromatography coupled with electrospray ionisation …

V Brighenti, M Licata, T Pedrazzi, D Maran… - … of Chromatography A, 2019 - Elsevier
Fibre-type Cannabis sativa L.(hemp) represents a valuable resource in many different fields,
including both the pharmaceutical and food ones. This plant contains non-psychoactive …

A conversion of oral cannabidiol to delta9-tetrahydrocannabinol seems not to occur in humans

G Nahler, F Grotenhermen, AW Zuardi… - Cannabis and …, 2017 - liebertpub.com
Cannabidiol (CBD), a major cannabinoid of hemp, does not bind to CB1 receptors and is
therefore devoid of psychotomimetic properties. Under acidic conditions, CBD can be …