Cystic fibrosis (CF) pathophysiology is hallmarked by excessive inflammation and the
inability to efficiently resolve lung infections, contributing to major morbidity and eventually …

Chronic lung disease has become a leading cause of death in recent years. Despite several
attempts to discover and develop new therapeutic approaches, patients often suffer a poor …

Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and
associated damaging products in the airway. Delayed neutrophil apoptosis is described in …

Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic
fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue …

Despite the addition of cystic fibrosis transmembrane conductance regulator (CFTR)
modulators to the cystic fibrosis (CF) treatment regimen, patients with CF continue to suffer …

Skeletal muscle atrophy with high prevalence can induce weakness and fatigability and
place huge burden on both health and quality of life. During skeletal muscle degeneration …

Albumin absorbed by renal tubular epithelial cells induces inflammation and plays a key role
in promoting diabetic kidney disease (DKD) progression. Macrophages are prominent …

Circular RNAs (circRNAs) constitute a class of covalently circular non-coding RNA
molecules formed by 5′ and 3′ end back-splicing. The rapid development of …

The molecular mechanism underlying denervation-induced muscle atrophy is complex and
incompletely understood. Our previous results suggested that inflammation may play an …

Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain
poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the …