Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

Genomic instability in the form of mutations and chromosome rearrangements is usually
associated with pathological disorders, and yet it is also crucial for evolution. Two types of …

Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA
replication, transcription, repair, and recombination. The extensive interactions between the …

The size of a eukaryotic genome presents a unique challenge to the cell: package and
organize the DNA to fit within the confines of the nucleus while at the same time ensuring …

Acetylation of histone H3 on lysine 56 occurs during mitotic and meiotic S phase in fungal
species. This acetylation blocks a direct electrostatic interaction between histone H3 and …

Genome instability is a hallmark of cancer cells, and defective DNA replication, repair and
recombination have been linked to its etiology. Increasing evidence suggests that proteins …

Multiple circuitries ensure that cells respond correctly to the environmental cues within
defined cellular programs. There is increasing evidence suggesting that cellular memory for …

The heterochromatic environment and physical clustering of chromosome ends at the
nuclear periphery provide a functional and structural framework for antigenic variation and …