Inherited genetic variation affects local gene expression and DNA methylation in humans.
Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a …

Progress in development of prognostic and therapeutic options for the rare cholestatic liver
diseases, primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), is …

White blood cells play diverse roles in innate and adaptive immunity. Genetic association
analyses of phenotypic variation in circulating white blood cell (WBC) counts from large …

The discovery of mitochondrial autoantigens recognized by antimitochondrial antibodies
(AMAs) in 1987 marked the dawn of a new era in primary biliary cholangitis (PBC) research …

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However,
much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing …

Patients with PBC are often asymptomatic and often left undiagnosed. There are no known
HLA and non-HLA alleles specific for PBC. Global effort and novel approaches such as …

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic
predisposition. Over the last decade, genome-wide association studies with increasing …

Within the spectrum of autoimmune diseases, Sjögren's syndrome and primary biliary
cholangitis are exemplary and can be coined as chronic epithelitis based on their frequent …

Abstract Motivation The results from Genome-Wide Association Studies (GWAS) on
thousands of phenotypes provide an unprecedented opportunity to infer the causal effect of …

Primary biliary cholangitis (PBC) is a chronic, slowly progressive cholestatic autoimmune
liver disease predominantly afflicting women. PBC is characterized by the presence of …