[HTML][HTML] Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach
The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …
transcription (STAT) transcription factors mediate intracellular signal transduction …
[HTML][HTML] The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Current and future status of JAK inhibitors
DP McLornan, JE Pope, J Gotlib, CN Harrison - The lancet, 2021 - thelancet.com
An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …
and activator of transcription (STAT) signalling in multiple disease states has led to an …
The role of JAK/STAT signaling pathway and its inhibitors in diseases
P Xin, X Xu, C Deng, S Liu, Y Wang, X Zhou… - International …, 2020 - Elsevier
The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …
transduction pathway and involved in many crucial biological processes, including cell …
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans
Silicone is widely used in chronic implants and is generally perceived to be safe. However,
textured breast implants have been associated with immune-related complications …
textured breast implants have been associated with immune-related complications …
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
SD Harding, JL Sharman, E Faccenda… - Nucleic acids …, 2018 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.
guidetopharmacology. org) and its precursor IUPHAR-DB, have captured expert-curated …
guidetopharmacology. org) and its precursor IUPHAR-DB, have captured expert-curated …
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
DM Schwartz, Y Kanno, A Villarino, M Ward… - Nature reviews Drug …, 2017 - nature.com
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
[HTML][HTML] JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
[HTML][HTML] The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
F Seif, M Khoshmirsafa, H Aazami… - Cell communication and …, 2017 - Springer
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …