Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles
Fungal infections of the paranasal cavity are among the most widely spread illnesses
nowadays. The aim of the current study was to estimate the effectiveness of an in situ gel …
nowadays. The aim of the current study was to estimate the effectiveness of an in situ gel …
[HTML][HTML] American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
SA Marques, MR Merlotto, PM Ramos… - Anais brasileiros de …, 2019 - SciELO Brasil
Pentavalent antimonials are the first-line drug treatment for American tegumentary
leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who …
leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who …
[HTML][HTML] Host defence peptides identified in human apolipoprotein B as promising antifungal agents
E Dell'Olmo, R Gaglione, A Cesaro, V Cafaro… - Applied Microbiology …, 2021 - Springer
Therapeutic options to treat invasive fungal infections are still limited. This makes the
development of novel antifungal agents highly desirable. Naturally occurring antifungal …
development of novel antifungal agents highly desirable. Naturally occurring antifungal …
Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects
V Aslanis, K Umehara, F Huth, T Ouatas… - Cancer Chemotherapy …, 2019 - Springer
Purpose Ruxolitinib is metabolized by cytochrome P450 (CYP) 3A4 and CYP2C9. Dual
inhibitors of these enzymes (like fluconazole) lead to increased ruxolitinib exposure relative …
inhibitors of these enzymes (like fluconazole) lead to increased ruxolitinib exposure relative …
[HTML][HTML] CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant …
Invasive fungal infections, which kill more than 1.6 million patients each year worldwide, are
difficult to treat due to the limited number of antifungal drugs (azoles, echinocandins, and …
difficult to treat due to the limited number of antifungal drugs (azoles, echinocandins, and …
[HTML][HTML] Isavuconazole exposure in critically ill patients treated with extracorporeal membrane oxygenation: two case reports and a narrative literature review
B Mertens, O Elkayal, E Dreesen, J Wauters… - Antibiotics, 2023 - mdpi.com
Effective dosing of isavuconazole in patients supported by extracorporeal membrane
oxygenation (ECMO) is important due to the role of isavuconazole as a first-line treatment in …
oxygenation (ECMO) is important due to the role of isavuconazole as a first-line treatment in …
[HTML][HTML] Species distribution of candidemia and their susceptibility in a single japanese university hospital: Prior micafungin use affects the appearance of candida …
Y Sakamoto, K Kawabe, T Suzuki, K Sano, K Ide… - Journal of Fungi, 2021 - mdpi.com
Introduction: Micafungin is a recommended echinocandin antifungal agent for candidemia
treatment and prophylaxis. However, overuse of echinocandin antifungals may cause …
treatment and prophylaxis. However, overuse of echinocandin antifungals may cause …
Azole antifungals and inter-individual differences in drug metabolism: the role of pharmacogenomics and precision medicine
M Biswas, J Shobana, P Jinda… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Azole antifungal drugs are commonly prescribed to treat invasive fungal
infections in various disease conditions. However, these drugs are substrates and inhibitors …
infections in various disease conditions. However, these drugs are substrates and inhibitors …
Successful enteral administration of crushed posaconazole delayed‐release tablets in children
LL Bio, L Hiroshima, HT Schwenk… - Pediatric Blood & …, 2024 - Wiley Online Library
Erratic absorption of posaconazole oral suspension necessitates frequent dosing and
administration with meals or supplements. Alternative enteral formulations are desirable for …
administration with meals or supplements. Alternative enteral formulations are desirable for …
Salting‐out homogeneous liquid‐liquid microextraction for the determination of azole drugs in human urine: Validation using total error concept
N Manousi, A Vlachaki, FS Kika… - Journal of …, 2022 - Wiley Online Library
A salting‐out homogeneous liquid‐liquid microextraction was proposed for the quantification
of four azole drugs in human urine prior to high‐performance liquid chromatography …
of four azole drugs in human urine prior to high‐performance liquid chromatography …