[HTML][HTML] Potential mechanisms of bisphenol A (BPA) contributing to human disease

I Cimmino, F Fiory, G Perruolo, C Miele… - International journal of …, 2020 - mdpi.com
Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce
polycarbonate plastic, widely used in the packaging for food and drinks, medical devices …

[HTML][HTML] An insight into GPCR and G-proteins as cancer drivers

PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

Estrogen synthesis and signaling pathways during aging: from periphery to brain

J Cui, Y Shen, R Li - Trends in molecular medicine, 2013 - cell.com
Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

The G-protein-coupled estrogen receptor GPER in health and disease

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2011 - nature.com
Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

Estrogen biology: new insights into GPER function and clinical opportunities

ER Prossnitz, M Barton - Molecular and cellular endocrinology, 2014 - Elsevier
Estrogens play an important role in the regulation of normal physiology, aging and many
disease states. Although the nuclear estrogen receptors have classically been described to …

[HTML][HTML] Estrogenic control of mitochondrial function

CM Klinge - Redox biology, 2020 - Elsevier
Sex-based differences in human disease are caused in part by the levels of endogenous
sex steroid hormones which regulate mitochondrial metabolism. This review updates a …

G protein-coupled receptors: novel targets for drug discovery in cancer

R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

[HTML][HTML] Extra-gonadal sites of estrogen biosynthesis and function

R Barakat, O Oakley, H Kim, J Jin, CMJ Ko - BMB reports, 2016 - ncbi.nlm.nih.gov
Estrogens are the key hormones regulating the development and function of reproductive
organs in all vertebrates. Recent evidence indicates that estrogens play important roles in …

Review of cadmium toxicity effects on fish: Oxidative stress and immune responses

JW Lee, AH Jo, DC Lee, CY Choi, JC Kang… - Environmental …, 2023 - Elsevier
Cadmium (Cd) in aquatic environments can cause environmental toxicity to fish and induce
oxidative stress owing to an excessive production of reactive oxygen species in fish bodies …

Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts

M Pupo, A Pisano, R Lappano… - Environmental …, 2012 - ehp.niehs.nih.gov
Background: Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water
bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by …