Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Background Current arthritis treatments often have side‐effects attributable to active
compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …

While acute inflammation is a natural physiological response to tissue injury or infection,
chronic inflammation is maladaptive and engenders a considerable amount of adverse pain …

The vanilloid receptor TRPV1 is a homotetrameric, non-selective cation channel abundantly
expressed in the nociceptors (c-fibers). TRPV1 is considered as a highly validated pain …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

Endovanilloids are defined as endogenous ligands and activators of transient receptor
potential (TRP) vanilloid type 1 (TRPV1) channels. The first endovanilloid to be identified …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …