Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

M Hrubša, T Siatka, I Nejmanová, M Vopršalová… - Nutrients, 2022 - mdpi.com
This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …

[HTML][HTML] Development and clinical application of phosphorus-containing drugs

H Yu, H Yang, E Shi, W Tang - Medicine in drug discovery, 2020 - Elsevier
Phosphorus-containing drugs belong to an important class of therapeutic agents and are
widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can …

Riboflavin transport and metabolism in humans

M Barile, TA Giancaspero, P Leone, M Galluccio… - Journal of inherited …, 2016 - Springer
Recent studies elucidated how riboflavin transporters and FAD forming enzymes work in
humans and create a coordinated flavin network ensuring the maintenance of cellular …

[HTML][HTML] Rethinking diet to aid human–microbe symbiosis

M Derrien, P Veiga - Trends in microbiology, 2017 - cell.com
The spread of the Western lifestyle has been accompanied by microbial changes thought to
underlie the emergence of chronic, nontransmissible, immune-related diseases. The past …

Riboflavin-responsive and-non-responsive mutations in FAD synthase cause multiple acyl-CoA dehydrogenase and combined respiratory-chain deficiency

RKJ Olsen, E Koňaříková, TA Giancaspero… - The American journal of …, 2016 - cell.com
Multiple acyl-CoA dehydrogenase deficiencies (MADDs) are a heterogeneous group of
metabolic disorders with combined respiratory-chain deficiency and a neuromuscular …

Discovery of potent and selective inhibitors against protein-derived electrophilic cofactors

X Wang, Z Lin, KA Bustin, NR McKnight… - Journal of the …, 2022 - ACS Publications
Electrophilic cofactors are widely distributed in nature and play important roles in many
physiological and disease processes, yet they have remained blind spots in traditional …

FAD-BERT: improved prediction of FAD binding sites using pre-training of deep bidirectional transformers

QT Ho, NQK Le, YY Ou - Computers in Biology and Medicine, 2021 - Elsevier
The electron transport chain is a series of protein complexes embedded in the process of
cellular respiration, which is an important process to transfer electrons and other …

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

A Salminen, A Haapasalo, A Kauppinen… - Progress in …, 2015 - Elsevier
The amyloid cascade hypothesis for the pathogenesis of Alzheimer's disease (AD) was
proposed over twenty years ago. However, the mechanisms of neurodegeneration and …

OCTN cation transporters in health and disease: role as drug targets and assay development

L Pochini, M Scalise, M Galluccio… - Journal of …, 2013 - journals.sagepub.com
The three members of the organic cation transporter novel subfamily are known to be
involved in interactions with xenobiotic compounds. These proteins are characterized by 12 …

Deep UV dispersion and absorption spectroscopy of biomolecules

S Soltani, A Ojaghi, FE Robles - Biomedical Optics Express, 2019 - opg.optica.org
Owing to the high precision and sensitivity of optical systems, there is an increasing demand
for optical methods that quantitatively characterize the physical and chemical properties of …