The evolving landscape of PD-1/PD-L1 pathway in head and neck cancer

X Qiao, J Jiang, X Pang, M Huang, Y Tang… - Frontiers in …, 2020 - frontiersin.org
Over the past 10 years, cancer immunotherapy has made significant progress in multiple
cancer types and has been gradually been applied to clinical cancer care, in which the …

Immune checkpoint inhibitors in oral cavity squamous cell carcinoma and oral potentially malignant disorders: a systematic review

O Kujan, B van Schaijik, CS Farah - Cancers, 2020 - mdpi.com
Cancers of the oral cavity cause significant cancer-related death worldwide. While survival
rates have improved in recent years, new methods of treatment are being investigated to …

Prognostic and clinicopathological significance of PD-L1 overexpression in oral squamous cell carcinoma: A systematic review and comprehensive meta-analysis

D Lenouvel, MÁ González-Moles, I Ruiz-Avila… - Oral oncology, 2020 - Elsevier
Abstract Background The presence of Programmed Death-Ligand 1 protein (PD-L1) in oral
squamous cell carcinoma (OSCC) may indicate an ability to evade immune response and …

PD-L1 evaluation in head and neck squamous cell carcinoma: Insights regarding specimens, heterogeneity and therapy

G Paolino, L Pantanowitz, V Barresi, F Pagni… - … -Research and Practice, 2021 - Elsevier
Immunohistochemical assessment with combined positive score (CPS) of programmed
death-ligand 1 (PD-L1) is the prerequisite for administration of checkpoint inhibitor therapy …

[HTML][HTML] The clinicopathological significance of PD-L1 expression assessed by the combined positive score (CPS) in head and neck squamous cell carcinoma

D Wusiman, L Guo, Z Huang, Z Li, S Liu, J Ying… - … -Research and Practice, 2022 - Elsevier
The expression of programmed cell death-ligand 1 (PD-L1) is being used as a predictive
biomarker for immunotherapy in head and neck squamous cell carcinoma (HNSCC). Our …

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

JCH Hsieh, HM Wang, MH Wu, KP Chang… - Head & …, 2019 - Wiley Online Library
Background Biomarkers in head and neck squamous cell carcinoma (HNSCC) emerge
rapidly in recent years, especially for new targeted therapies and immunotherapies …

Who is who in oral cancer?

W Zhang, S Wang, H Wang, YJ Tang, Y Tang… - Experimental Cell …, 2019 - Elsevier
Great attention has been attached to explore the association between oral bacteria and oral
cancer. Recently, four common inhabitants of oral cavity, Porphyromonas gingivalis …

Prognostic value of PD-1, PD-L1 and PD-L2 deserves attention in head and neck cancer

S Jiang, X Li, L Huang, Z Xu, J Lin - Frontiers in Immunology, 2022 - frontiersin.org
Head and neck cancer has high heterogeneity with poor prognosis, and emerging
researches have been focusing on the prognostic markers of head and neck cancer. PD-L1 …

Tissue and circulating PD-L2: Moving from health and immune-mediated diseases to head and neck oncology

E Muraro, R Romanò, G Fanetti, E Vaccher… - Critical reviews in …, 2022 - Elsevier
Amongst the chief targets of immune-checkpoint inhibitors (ICIs), namely the Programmed
cell death protein 1 (PD-1)/PD-Ligands (Ls) axis, most research has focused on PD-L1 …

The microenvironment of head and neck cancers: papillomavirus involvement and potential impact of immunomodulatory treatments

S Outh-Gauer, A Morini, E Tartour, C Lépine… - Head and Neck …, 2020 - Springer
Cancer progression can be understood as the result of deregulation of tumors' immune
microenvironments. Recent studies of the alterations of microenvironments highlight their …