Molecular mechanisms of antibiotic resistance revisited

EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence

E Christaki, M Marcou, A Tofarides - Journal of molecular evolution, 2020 - Springer
In recent years, we have seen antimicrobial resistance rapidly emerge at a global scale and
spread from one country to the other faster than previously thought. Superbugs and …

Methicillin-resistant Staphylococcus aureus

AS Lee, H De Lencastre, J Garau… - Nature reviews Disease …, 2018 - nature.com
Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged,
disseminated globally and become a leading cause of bacterial infections in both health …

[HTML][HTML] Vancomycin resistant Staphylococcus aureus infections: A review of case updating and clinical features

Y Cong, S Yang, X Rao - Journal of advanced research, 2020 - Elsevier
The infection caused by methicillin-resistant Staphylococcus aureus (MRSA) is a global
threat to public health. Vancomycin remains one of the first-line drugs for the treatment of …

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

SW Dickey, GYC Cheung, M Otto - Nature Reviews Drug Discovery, 2017 - nature.com
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens
are outpacing the development of new antibiotics, but antivirulence agents provide an …

Futuristic non-antibiotic therapies to combat antibiotic resistance: A review

M Kumar, DK Sarma, S Shubham, M Kumawat… - Frontiers in …, 2021 - frontiersin.org
The looming problem of resistance to antibiotics in microorganisms is a global health
concern. The drug-resistant microorganisms originating from anthropogenic sources and …

Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates

Q Wu, N Sabokroo, Y Wang, M Hashemian… - … Resistance & Infection …, 2021 - Springer
Abstract Background Vancomycin‑resistant Staphylococcus aureus (VRSA) is a serious
public health challenging concern worldwide. Objectives Therefore, the objective of present …

Tackling threats and future problems of multidrug-resistant bacteria

E Medina, DH Pieper - How to overcome the antibiotic crisis: facts …, 2016 - Springer
With the advent of the antibiotic era, the overuse and inappropriate consumption and
application of antibiotics have driven the rapid emergence of multidrug-resistant pathogens …

Mechanisms of vancomycin resistance in Staphylococcus aureus

S Gardete, A Tomasz - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial
infections. Traditionally, it has been used as a drug of last resort; however, clinical isolates of …

Predictors of mortality in Staphylococcus aureus bacteremia

SJ Van Hal, SO Jensen, VL Vaska… - Clinical microbiology …, 2012 - Am Soc Microbiol
Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate
ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these …