The explosion of high throughput sequencing technologies marked a turn in our way of
understanding the complexity and diversity of the transcriptome, including noncoding …

Enhancers are DNA elements that increase gene expression. mRNA production is
determined by transcript production and polyadenylation site (PAS) cleavage activity. We …

Most functional eukaryotic mRNAs contain a 7-methylguanosine (m7G) cap which serves as
a platform that recruits proteins to support essential biological functions such as mRNA …

Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly
interleaved transcriptome organization that involves thousands of coding and non‐coding …

Pontocerebellar hypoplasia (PCH) is a group of autosomal recessive disorders caused by
mutations in one of several genes (Table 3.1). Amino acid substitutions in EXOSC3, the …

Unstable non-coding RNAs are produced from thousands of loci in all studied eukaryotes
(and also prokaryotes), but remain of largely unknown function. The present review …

Proteins that bind the nascent transcript exiting RNA polymerase II (RNAP II) can regulate
transcription elongation. The essential Saccharomyces cerevisiae hnRNP protein Hrp1 is …

Eukaryotic RNA turnover is regulated in part by the exosome, a nuclear and cytoplasmic
complex of ribonucleases (RNases) and RNA-binding proteins. The major RNase of the …

Parmi les différents acteurs impliqués dans le dogme de la biologie moléculaire, les
protéines sont des unités biologiques fonctionnelles contribuant à de nombreux processus …

Cells change their physiological state in response to environmental cues. In the absence of
nutrients, unicellular fungi such as budding yeast exit mitotic proliferation and enter the …