Pontocerebellar hypoplasia (PCH) is a group of autosomal recessive disorders caused by
mutations in one of several genes (Table 3.1). Amino acid substitutions in EXOSC3, the …

Unstable non-coding RNAs are produced from thousands of loci in all studied eukaryotes
(and also prokaryotes), but remain of largely unknown function. The present review …

Eukaryotic RNA turnover is regulated in part by the exosome, a nuclear and cytoplasmic
complex of ribonucleases (RNases) and RNA-binding proteins. The major RNase of the …

Parmi les différents acteurs impliqués dans le dogme de la biologie moléculaire, les
protéines sont des unités biologiques fonctionnelles contribuant à de nombreux processus …

The transcription of messenger RNA (mRNA) is a complex process implicating a large
diversity of players at very specific steps. The production of an mRNA also requires its …

Cells change their physiological state in response to environmental cues. In the absence of
nutrients, unicellular fungi such as budding yeast exit mitotic proliferation and enter the …

Abstract Non-coding RNAs (ncRNAs), including the more recently identified Stable
Unannotated Transcripts (SUTs) and Cryptic Unstable Transcripts (CUTs), are increasingly …

Proteins that bind the nascent transcript exiting RNA polymerase II (RNAP II) can regulate
transcription elongation. The essential Saccharomyces cerevisiae hnRNP protein Hrp1 is …

The 5'RNA capping is an essential process conserved in the entire eukaryotic kingdom. It
consists in the co-transcriptional addition of a 7-methylguanosine (m\(^ 7\) G) residue to the …

RNA exosomopathies, a growing family of tissue-specific diseases, are linked to missense
mutations in genes encoding the structural subunits of the highly conserved 10-subunit …