Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …

Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …

From the development of self-aggregating, scaffold-free multicellular spheroids to the
inclusion of scaffold systems, 3D models have progressively increased in complexity to …

Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest
on the endothelium, transendothelial migration (TEM), followed by the invasion into the …

Hepatocellular carcinoma (HCC) cells, especially those with metastatic competence, show
reduced stiffness compared to the non-malignant counterparts. However, it is still unclear …

Emerging microfluidic disease models have amply demonstrated their value in many fields
of cancer research. These in vitro technologies recapitulate key aspects of metastatic …

Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the
tumour microenvironment and allow for the study of dynamic interactions that occur during …

The vasculature plays a critical role in cancer progression and metastasis, representing a
pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on …

With the development of microfluidic technology, tumor-on-chip models have gradually
become a new tool for the study of breast cancer because they can simulate more key …