Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?

MAM Freire, GS Rocha, LO Bittencourt, D Falcao… - Biology, 2023 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …

Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics

S Fang, Z Wu, Y Guo, W Zhu, C Wan, N Yuan… - Frontiers in …, 2023 - frontiersin.org
Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells
in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural …

Matrine mediated neuroprotective potential in experimental multiple sclerosis: evidence from CSF, blood markers, brain samples and in-silico investigations

S Chhabra, S Mehan, Z Khan, GD Gupta… - Journal of …, 2023 - Elsevier
Multiple sclerosis (MS) is a debilitating, inflammatory, and demyelinating disease of the
central nervous system influenced by environmental and genetic factors. Around 2.8 million …

Neuron-specific enolase (NSE) as a biomarker for autistic spectrum disease (ASD)

F Stancioiu, R Bogdan, R Dumitrescu - Life, 2023 - mdpi.com
Autistic spectrum disease (ASD) is an increasingly common diagnosis nowadays with a
prevalence of 1–2% in most countries. Its complex causality—a combination of genetic …

Therapeutic modulators inhibiting neuromuscular and motor neuron degeneration

S Mehan - Frontiers in neuroscience, 2023 - frontiersin.org
In recent decades, the global prevalence of brain illnesses has increased, as has the
disease's socioeconomic impact. A rise in 5% of motor neuron disorders (MNDs) and …

Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF …

S Kumar, S Mehan, Z Khan, G Das Gupta… - Molecular …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a paralytic disease that damages the brain and spinal
cord motor neurons. Several clinical and preclinical studies have found that methylmercury …

Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT …

S Chen, C Li, Z Tu, T Cai, X Zhang, L Wang… - Frontiers in …, 2024 - frontiersin.org
As an inflammatory disease with a disrupted immune system, cytokine disorders in atopic
dermatitis (AD) are closely related to the abnormal activation of JAK-STAT signal pathway …

Buyang Huanwu Decoction promotes the neurological recovery of traumatic spinal cord injury via inhibiting apoptosis, inflammation, and oxidative stress

X Li, Y Song, Y Yang, G Zhang - Immunity, inflammation and …, 2023 - Wiley Online Library
Background The incidence rate of spinal cord injury (SCI) is increasing, and the mortality or
disability rate caused by SCI remains high in the world. Buyang Huanwu Decoction …

[HTML][HTML] Understanding the link between immunosuppressant and natural killer cell in the progression of autism: The role of natural killer cell and mammalian target of …

P Anandand, S Singh - Advanced Neurology, 2023 - accscience.com
Natural killer cell plays a major role in the pathogenesis of neurodevelopmental disorder
including autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder that is …

[HTML][HTML] The Effect of JAK Inhibitors on Patient-Reported Outcomes in Psoriatic Arthritis

SG Tsiogkas, C Perricone… - Mediterranean Journal of …, 2024 - ncbi.nlm.nih.gov
Objective: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints
and skin of patients with psoriasis. In this review we aimed to summarise the available …