Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI)
formulations. Numerous inhalation therapies have been developed using lactose as a …

Pulmonary administration of dry powder formulation presents several advantages in the
treatment of respiratory diseases. Since micronized drug particles are very cohesive and …

Orally inhaled products (OIPs) are gaining increased attention, as pulmonary delivery is a
preferred route for the treatment of various diseases. Yet, the field of inhalation …

The feasibility of twin-screw corotating extruder as a continuous process mixer to prepare
dry powder inhalation (DPI) powders was investigated. Interactive mixtures of 1 …

We present a numerical study of bulk properties of binary particle blends via DEM.
Properties of settled particle bulks, such as packing fraction, are computed. We investigated …

Tertiary lactose has been shown to improve aerosolization performance of carrier-based dry
powder inhalation formulations. The working mechanism of the tertiary lactose, however, is …

Novel d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles containing the
anti-cancer drug artesunate (ART) were developed in a dry powder form for inhalation for …

In this chapter, the authors propose techniques based on the US Food and Drug
Administration (FDA)'s current good machine learning practices in order to improve the …

Dry powder inhalers (DPIs) have attracted enormous attention worldwide due to its local
targeting, rapid drug effect and reduced systemic toxicity. However, DPI formulations consist …

The GranuPack conducts an automated tapped density measurement characterising the
packing dynamics of a powder. It consists of a steel cylindrical cell, 26 mm in diameter and …