Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

The mechanisms responsible for radioresistance in pancreatic cancer have yet to be
elucidated, and the suppressive tumor immune microenvironment must be considered. We …

Abstract Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter known to affect
emotion, behavior, and cognition, and its effects are mostly studied in neurological diseases …

Platelet-derived peripheral serotonin has pleiotropic effects on coagulation, metabolism,
tissue regeneration, and cancer growth; however, the effect of serotonin on the tumor …

Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

Background Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several
human malignancies, including hepatocellular carcinoma (HCC). However, the role of …

Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC).
Here, we investigated the effect of perineural invasion on the microenvironment and how …

Reprogrammed energy metabolism, especially the Warburg effect (aerobic glycolysis), is an
emerging hallmark of cancer. Different from other breast cancer subtypes, triple-negative …