An overview of Nrf2 signaling pathway and its role in inflammation

S Saha, B Buttari, E Panieri, E Profumo, L Saso - Molecules, 2020 - mdpi.com
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

L Wang, C He - Frontiers in immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

The role of hydrogen peroxide in redox-dependent signaling: homeostatic and pathological responses in mammalian cells

N Di Marzo, E Chisci, R Giovannoni - Cells, 2018 - mdpi.com
Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox
metabolism reactions and processes of the cells. H2O2 is recognized as one of the main …

NF‐κB and the link between inflammation and cancer

JA DiDonato, F Mercurio, M Karin - Immunological reviews, 2012 - Wiley Online Library
The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy

SN Rai, N Tiwari, P Singh, D Mishra, AK Singh… - Frontiers in …, 2021 - frontiersin.org
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)

V Sharma, D Anderson, A Dhawan - Apoptosis, 2012 - Springer
The wide scale use of Zinc oxide (ZnO) nanoparticles in the world consumer market makes
human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. The …

NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases

A Fiordelisi, G Iaccarino, C Morisco, E Coscioni… - International journal of …, 2019 - mdpi.com
Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of
atherosclerosis and a significant risk factor for the development of cardiovascular events. In …

Nuclear factor-κB in cancer development and progression

M Karin - Nature, 2006 - nature.com
Nuclear factor-κB (NF-κB) transcription factors and the signalling pathways that activate
them are central coordinators of innate and adaptive immune responses. More recently, it …

Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers

EV Batrakova, AV Kabanov - Journal of controlled release, 2008 - Elsevier
Polymer nanomaterials have sparked a considerable interest as vehicles used for diagnostic
and therapeutic agents; research in nanomedicine has not only become a frontier movement …

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

R Wilken, MS Veena, MB Wang, ES Srivatsan - Molecular cancer, 2011 - Springer
Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant,
commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine …