In the combat of treating cancer recent therapeutic approaches are focused towards
enzymatic targets as they occupy a pivotal participation in the cascade of oncogenesis and …

Marine invertebrates are extremely diverse, largely productive, untapped oceanic resources
with chemically unique bioactive lead compound contributing a wide range of screening for …

To characterize largazole's structural requirements for histone deacetylase (HDAC)
inhibitory and antiproliferative activities, a series of analogues with modifications to the side …

Histone deacetylases (HDACs) are a family of enzymes found in bacteria, fungi, plants, and
animals that profoundly affect cellular function by catalyzing the removal of acetyl groups …

Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many
marine-derived natural products and their analogues have been reported to show …

Marine invertebrates are rich sources of small molecules with unique chemical skeletons
and potent bioactivities. Historically, such compounds were discovered mainly through the …

Histone deacetylase (HDAC) inhibitors are powerful tools in understanding epigenetic
regulation and have proven especially promising for the treatment of various cancers, but …

Over the past seven decades, particularly since the discovery of the first marine-derived
nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya …

Histone deacetylases (HDACs) remove acetyl groups from the tails of lysine residues of
histone protein in nuclear chromatin and also from acetylated sites in non-histone proteins …

Covering: up to 2009 A number of small-molecule natural products have been shown to
inhibit the activity of histone deacetylases (HDACs). These enzymes catalyze the hydrolysis …