A copper (I)‐mediated denitrogenative reaction has been successfully developed for the
preparation of cyclic tetrapeptides. The key reactive intermediate, ketenimine, triggers …

Natural, nonribosomal cyclotetrapeptides have traditionally been a rich source of inspiration
for design of potent histone deacetylase (HDAC) inhibitors. We recently disclosed the total …

Histone deacetylase (HDAC) inhibitors have attracted considerable attention due to their
promise as therapeutic agents. Most HDAC inhibitors adhere to a general “cap-linker-Zn2+ …

The study of epigenetic translational modifications had drawn great interest for the last few
decades. These processes play a vital role in many diseases and cancer is one of them …

The present study describes the synthesis and biological studies of a small series of head‐to‐
tail cyclic tetrapeptides of the general structure c (Lys‐β2, 2‐Xaa‐Lys) containing one …

Sponges (phylum Porifera), often called 'living fossils' or 'most primitive multicellular
animals', are the first metazoans evolved from a common ancestor termed Urmetazoa 1 …

The designed β2, 3 unnatural amino acids have been synthesized from α‐methyl‐β‐
hydroxycarbamides via direct azidation without obtaining eliminated products. Furthermore …

The cyclization of the linear tetrapeptides sequence H‐NMePhe‐Xaa1‐NMePhe‐Xaa2‐OH
(for which Xaa1= Xaa2= Ile, Val, or Leu; Xaa1= Val; Xaa2= Ile or Leu) by using 1 …

Sponges are a useful source of bioactive natural products. Members of the family Mycalidae,
in particular, have provided a variety of chemical structures including alkaloids, polyketides …

The natural environment is replete with potent bioactive organic molecules that are
produced by the microorganisms that inhabit it. These so-called secondary metabolites …