[HTML][HTML] Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

[HTML][HTML] Anti-inflammatory drugs as anticancer agents

S Zappavigna, AM Cossu, A Grimaldi… - International journal of …, 2020 - mdpi.com
Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

Modern advances in heterocyclic chemistry in drug discovery

AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells

M Fujita, G Kohanbash, W Fellows-Mayle, RL Hamilton… - Cancer research, 2011 - AACR
Epidemiologic studies have highlighted associations between the regular use of
nonsteroidal anti-inflammatory drugs (NSAID) and reduced glioma risks in humans. Most …

[HTML][HTML] Anti-inflammatory agents for cancer therapy

ER Rayburn, SJ Ezell, R Zhang - Molecular and cellular …, 2009 - ncbi.nlm.nih.gov
Inflammation is closely linked to cancer, and many anti-cancer agents are also used to treat
inflammatory diseases, such as rheumatoid arthritis. Moreover, chronic inflammation …

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

AH Schönthal - Biochemical pharmacology, 2013 - Elsevier
The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …

Targeting apoptosis pathways by Celecoxib in cancer

V Jendrossek - Cancer letters, 2013 - Elsevier
Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …

Recent advances in the anticancer applications of benzimidazole derivatives

M Mavvaji, S Akkoc - ChemistrySelect, 2023 - Wiley Online Library
Cancer, one of the most deadly diseases worldwide, is still a crucial challenge to human
well‐being. Hence, the design and development of modern protocols to cure diverse kinds …

Recent update on anti-dengue drug discovery

SN Dighe, K Dua, DK Chellappan, PL Katavic… - European journal of …, 2019 - Elsevier
Dengue is the most important arthropod-borne viral disease of humans, with more than half
of the global population living in at-risk areas. Despite the negative impact on public health …

Endoplasmic reticulum stress and autophagy as targets for cancer therapy

AH Schönthal - Cancer letters, 2009 - Elsevier
The endoplasmic reticulum stress (ERS) response represents an adaptive mechanism that
supports survival and chemoresistance of tumor cells. Autophagy, although less well …