A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …

Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral
cues can acquire motivational properties when paired with the positive emotional effects of …

The development of physical dependence and addiction disorders due to misuse of opioid
analgesics is a major concern with pain therapeutics. We developed a mouse model of …

Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current
opioid epidemic. There are several challenges with modelling oxycodone abuse. First …

Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

Withdrawal from opioids involves a negative affective state that promotes maintenance of
drug-seeking behavior and relapse. As such, understanding the neurobiological …

Rationale Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence
indicating that OUD may be particularly severe for women, preclinical models have yet to …

Animal models of addictive behaviors are useful for uncovering neural mechanisms involved
in the development of dependence and for identifying risk factors for drug abuse. One such …

Background: The Department of Health and Human Services reports that prescription pain
reliever (eg, oxycodone) misuse was initiated by 4,400 Americans each day in 2019. Amid …

The effectiveness of current treatments for opioid use disorder (OUD) varies by sex. Our
understanding of the neurobiological mechanisms mediating negative states during …