All about (NK cell-mediated) death in two acts and an unexpected encore: initiation, execution and activation of adaptive immunity
A Ramírez-Labrada, C Pesini, L Santiago… - Frontiers in …, 2022 - frontiersin.org
NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …
transformed cells, being one of the main executors of cell death in the immune system. NK …
Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity
Cytotoxic lymphocytes are critical in our immune defence against cancer and infection.
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …
Lysosomal cell death mechanisms in aging
R Gómez-Sintes, MD Ledesma, P Boya - Ageing research reviews, 2016 - Elsevier
Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety
of processes, from calcium signaling and nutrient responses to autophagic degradation of …
of processes, from calcium signaling and nutrient responses to autophagic degradation of …
The role of cysteine cathepsins in cancer progression and drug resistance
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their
expression is misregulated in a wide variety of tumors, and ample data prove their …
expression is misregulated in a wide variety of tumors, and ample data prove their …
Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases
Cathepsins are an important category of enzymes that have attracted great attention for the
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …
Cystatins in cancer progression: More than just cathepsin inhibitors
Cystatins are endogenous and reversible inhibitors of cysteine peptidases that are important
players in cancer progression. Besides their primary role as regulators of cysteine peptidase …
players in cancer progression. Besides their primary role as regulators of cysteine peptidase …
Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
Single cell transcriptomics of Atlantic salmon (Salmo salar L.) liver reveals cellular heterogeneity and immunological responses to challenge by Aeromonas …
The liver is a multitasking organ with essential functions for vertebrate health spanning
metabolism and immunity. In contrast to mammals, our understanding of liver cellular …
metabolism and immunity. In contrast to mammals, our understanding of liver cellular …
SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry
O Matveeva, Y Nechipurenko, D Lagutkin… - Frontiers in …, 2022 - frontiersin.org
Our review summarizes the evidence that COVID-19 can be complicated by SARS-CoV-2
infection of immune cells. This evidence is widespread and accumulating at an increasing …
infection of immune cells. This evidence is widespread and accumulating at an increasing …
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
G Arbore, EE West, J Rahman, G Le Friec… - Nature …, 2018 - nature.com
The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement
receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome …
receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome …