Nanosizing is an approach to improve the dissolution rate of poorly soluble drugs. The first
aim of this work was to develop nanosuspension of cilostazol with liquid antisolvent …

A growing number of poorly water-soluble drug have been discovered, but the poor
bioavailability is a critical problem. In this study, physical properties and dissolution profiles …

Crystallization of the metastable polymorph of paracetamol has been shown to occur around
the edge of an evaporating aqueous solution. Conditions at the edge of a meniscus during …

Purpose: The aim of this study was to develop cilostazol (CLT) nanocrystals intended to
improve its dissolution rate and enhance its bioavailability. Methods: In this study, CLT …

The aim of this study was to improve wettability and dissolution rate of a poorly water-soluble
drug, cilostazol, using the supercritical antisolvent (SAS) process. The solid state of particles …

Improvement in dissolution of the drugs having poor solubility is a challenge in
pharmaceutical industry. Micronization is one technique, employed for dissolution …

The therapeutic usage of cilostazol is limited owing to its poor aqueous solubility and oral
bioavailability. Our aim was to produce cilostazol crystals with small average particle size; …

It is now very well known that the majority of organic compounds are capable of being
crystallized into more than one structural form (1-11). Polymorphism is defined as the …

Spironolactone form I melts at about 70 degrees lower than form II, which is very unusual for
two co-existing polymorphs. The phase relationships involving this unprecedented case of …

In this work, the antisolvent membrane crystallization process has been used to influence
the polymorphic composition in the crystallization of l-histidine. When finely dosing the …