Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

Summary Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …

Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut
microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important …

The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

Hypercholesterolemia plays a causal role in the development of atherosclerosis and is one
of the main risk factors for cardiovascular disease (CVD), the leading cause of death …

The mechanisms by which the early-life microbiota protects against environmental factors
that promote childhood obesity remain largely unknown. Using a mouse model in which …

The human gut microbiome constantly converts natural products derived from the host and
diet into numerous bioactive metabolites,–. Dietary fats are essential micronutrients that …