[HTML][HTML] Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from …
HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia,
progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in …
progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in …
Nef, the shuttling molecular adaptor of HIV, influences the cytokine network
Several viruses manipulate host innate immune responses to avoid immune recognition and
improve viral replication and spreading. The viral protein Nef of Human Immunodeficiency …
improve viral replication and spreading. The viral protein Nef of Human Immunodeficiency …
[HTML][HTML] Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network
A very small proportion of people remain negative for HIV infection after repeated HIV-1 viral
exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 …
exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 …
The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS
M Giovanna Quaranta, B Mattioli, L Giordani… - The FASEB …, 2006 - Wiley Online Library
Dendritic cells (DC) play a crucial role in the generation and regulation of immunity, and
their interaction with HIV is relevant in the pathogenesis of AIDS favoring both the initial …
their interaction with HIV is relevant in the pathogenesis of AIDS favoring both the initial …
[HTML][HTML] Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner
Human immunodeficiency virus-1 (HIV-1) exploits a number of host cellular factors for
successful survival and propagation. The viral protein Nef plays an important role in HIV-1 …
successful survival and propagation. The viral protein Nef plays an important role in HIV-1 …
[HTML][HTML] Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranes
Nef is an HIV-1 accessory protein that directly contributes to AIDS progression. Nef is
myristoylated on the N-terminus, associates with membranes, and may undergo a transition …
myristoylated on the N-terminus, associates with membranes, and may undergo a transition …
Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children
DB Tzitzivacos, CT Tiemessen, WS Stevens… - AIDS research and …, 2009 - liebertpub.com
Abstract Characterization of HIV-1 from slow progressors is important to facilitate vaccine
and antiviral drug development. To identify virus attenuations that may contribute to slower …
and antiviral drug development. To identify virus attenuations that may contribute to slower …
[HTML][HTML] CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages
TO Robinson, M Zhang, C Ochsenbauer, LE Smythies… - Virology, 2017 - Elsevier
Previous in vitro studies have shown that the HIV-1 virus can alter the cytokine/chemokine
profile of polarized macrophages which may lead to their increased susceptibility to viral …
profile of polarized macrophages which may lead to their increased susceptibility to viral …
Effects of HIV-1 Nef on Human N-Myristoyltransferase 1
CR Morgan, BV Miglionico, JR Engen - Biochemistry, 2011 - ACS Publications
The HIV-1 accessory protein Nef is N-terminally myristoylated, and this post-translational
modification is essential for Nef function in AIDS progression. Transfer of a myristate group …
modification is essential for Nef function in AIDS progression. Transfer of a myristate group …
Genomic Diversity in the Regulatory nef Gene Sequences in Indian Isolates of HIV Type 1: Emergence of a Distinct Subclade and Predicted Implications
The regulatory functional nef gene is known to mediate a cascade of events during
pathogenesis in HIV infection. Variability in the nef gene sequences of HIV-1 A and B …
pathogenesis in HIV infection. Variability in the nef gene sequences of HIV-1 A and B …