How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Peripheral artery disease: epidemiology and global perspectives

FGR Fowkes, V Aboyans, FJI Fowkes… - Nature Reviews …, 2017 - nature.com
Global populations are undergoing a major epidemiological transition in which the burden of
atherosclerotic cardiovascular diseases is shifting rapidly from high-income to low-income …

Role of gut microbiota in atherosclerosis

AL Jonsson, F Bäckhed - Nature Reviews Cardiology, 2017 - nature.com
Infections have been linked to the development of cardiovascular disease and
atherosclerosis. Findings from the past decade have identified microbial ecosystems …

Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction

PC Westman, MJ Lipinski, D Luger, R Waksman… - Journal of the American …, 2016 - jacc.org
Abstract Treatment of acute myocardial infarction (AMI) has improved significantly in recent
years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive …

The dormant blood microbiome in chronic, inflammatory diseases

M Potgieter, J Bester, DB Kell… - FEMS microbiology …, 2015 - academic.oup.com
Blood in healthy organisms is seen as a 'sterile'environment: it lacks proliferating microbes.
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology

L Reyes, D Herrera, E Kozarov… - Journal of clinical …, 2013 - Wiley Online Library
Objective The objective of this review was to perform a systematic evaluation of the literature
reporting current scientific evidence for periodontal bacteria as contributors to …

Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis

ME Rosenfeld, LA Campbell - Thrombosis and haemostasis, 2011 - thieme-connect.com
It is currently unclear what causes the chronic inflammation within atherosclerotic plaques.
One emerging paradigm suggests that infection with bacteria and/or viruses can contribute …

Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States

AM Simanek, JB Dowd, G Pawelec, D Melzer, A Dutta… - PloS one, 2011 - journals.plos.org
Background Studies have suggested that CMV infection may influence cardiovascular
disease (CVD) risk and mortality. However, there have been no large-scale examinations of …

Cytomegalovirus infection and relative risk of cardiovascular disease (ischemic heart disease, stroke, and cardiovascular death): a meta‐analysis of prospective …

H Wang, G Peng, J Bai, B He, K Huang… - Journal of the …, 2017 - Am Heart Assoc
Background Several studies have suggested that cytomegalovirus infection is likely
associated with an increased relative risk of cardiovascular disease (CVD); however, the …