Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are
involved in movement control and reward-related cognition. In Parkinson's disease …

Although cell transplantation can rescue motor defects in Parkinson's disease (PD) models,
whether and how grafts functionally repair damaged neural circuitry in the adult brain is not …

In Parkinson's disease (PD), there are currently no effective therapies to prevent or slow
down disease progression. Cell replacement therapy using human pluripotent stem cell …

Midbrain dopamine (mDA) neurons can be replaced in patients with Parkinson's disease
(PD) in order to provide long-term improvement in motor functions. The limited capacity for …

Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is
characterized by degeneration of dopaminergic neurons (DA) at the substantia nigra pas …

Human in vitro models of neural tissue with tunable microenvironment and defined spatial
arrangement are needed to facilitate studies of brain development and disease. Towards …

Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in
Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin …