Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

[HTML][HTML] Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

[HTML][HTML] Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches

B Jahangiri, AK Saei, PO Obi, N Asghari… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Exosomal release pathway and autophagy together maintain homeostasis and survival of
cells under stressful conditions. Autophagy is a catabolic process through which cell entities …

[HTML][HTML] Astrocytic MicroRNAs and transcription factors in Alzheimer's disease and therapeutic interventions

A Nassar, T Kodi, S Satarker, P Chowdari Gurram… - Cells, 2022 - mdpi.com
Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and
neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to …

[HTML][HTML] A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection

A Gorgzadeh, A Nazari, A Ali Ehsan Ismaeel… - Virology Journal, 2024 - Springer
Abstract Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular
components found in exosomes released by tumor cells. They play an essential role in …

[HTML][HTML] Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism

Y Fu, S Xiong - PLoS pathogens, 2023 - journals.plos.org
Specific virus-receptor interactions are important determinants in viral host range, tropism
and pathogenesis, influencing the location and initiation of primary infection as well as viral …

Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside

VA dos Santos Valsecchi, FR Betoni, LS Ward… - Reviews in Endocrine …, 2024 - Springer
The recent incorporation of immune checkpoint inhibitors targeting the PD-1 (programmed
cell death receptor 1) and CTLA-4 (cytotoxic T lymphocyte antigen 4) pathways into the …

[HTML][HTML] Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis

DS Mysiris, GD Vavougios, E Karamichali… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease after
Alzheimer's disease, globally. Dopaminergic neuron degeneration in substantia nigra pars …

Rapid and Highly Efficient Purification of Extracellular Vesicles Enabled by a TiO2 Hybridized Spongy-like Polymer

E Kanao, K Ishida, R Mizuta, Y Li, K Imami… - Analytical …, 2023 - ACS Publications
We developed a novel purification medium of extracellular vesicles (EVs) by constructing a
spongy-like monolithic polymer kneaded with TiO2 microparticles (TiO2-hybridized spongy …

Exosomes in COVID‐19 infection: Focus on role in diagnosis, pathogenesis, immunity, and clinical trials

A Aljuhani, O Albalawi, R Albalawi… - Cell Biology …, 2023 - Wiley Online Library
Since the end of 2019, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
spread as a new strain of coronavirus disease (COVID‐19) and progressed as a global …