HER2 is an established prognostic and predictive marker for patients with invasive breast
cancer. The clinical and biological significance of HER2 overexpression in patients with …

Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

Various studies have evaluated the significance of PTEN (phosphatase and tensin homolog
deleted from chromosome 10) expression in breast cancer, but their results remain …

Endometrial cancer is the most common gynecologic cancer in the United States, diagnosed
in more than 50,000 women annually. While the majority of women present with low-grade …

Precision medicine approaches have found applications in the treatment of several tumor
types and have led to rapid advancement in the number of available therapies for some …

PIK 3 CA is an oncogene that encodes the p110α component of phosphatidylinositol 3‐
kinase (PI 3K); it is the second most frequently mutated gene following the TP 53 gene. In …

Breast cancer (BCa) is the most common cancer and the second cause of death among
women. Phosphoinositide 3-kinase (PI3K) signaling pathway has a crucial role in the …

MicroRNAs are a class of small non-coding RNAs that play essential roles in cancer
development and progression. Recent studies suggested that abnormal expression of …

Background This study aimed to comprehensively explore the clinical significance of
PIK3CA mutation in human epidermal growth factor receptor 2 (HER2)-positive breast …

Purpose: Despite the substantial progress in the development of targeted anticancer drugs,
treatment failure due to primary or acquired resistance is still a major hurdle in the effective …