The catalytic subunit of yeast telomerase, Est2p, is a telomere associated throughout most of
the cell cycle, while the Est1p subunit binds only in late S/G2 phase, the time of telomerase …

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human
genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile …

Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant
lengthening or reduction in the length of telomeres can lead to health anomalies, such as …

DNA double-strand breaks (DSBs) are a threat to cell survival and genome integrity. In
addition to canonical DNA repair systems, DSBs can be converted to telomeres by …

The Saccharomyces cerevisiae CDC13 protein binds single-strand telomeric DNA. Here we
report the isolation of new mutant alleles of CDC13 that confer either abnormal telomere …

While most cancer cells rely on telomerase expression/re-activation for linear chromosome
maintenance and sustained proliferation, a significant population of cancers (10–15%) …

Werner syndrome is a Mendelian disorder of man that produces a number of manifestations
resembling human aging. This disorder is caused by inactivation of the wrn gene, a member …

Telomeres are eukaryotic protein–DNA complexes found at the ends of linear chromosomes
that are essential for maintaining genome integrity and are implicated in cellular aging and …

Telomerase counteracts loss of terminal sequences incurred during DNA replication. In S.
cerevisiae, telomerase contains an RNA template (TLC1), a reverse transcriptase (Est2p) …

The repair of spontaneous or induced DNA damage by homologous recombination (HR) in
Saccharomyces cerevisiae will suppress chromosome rearrangements. Alternative …