DNA polymerase _ (pol _) holds a special position among the growing family of eukaryotic
DNA polymerases. In fact, pol _ is associated with DNA primase to form a four subunit …

Studies of the DNA polymerase III holoenzyme of Escherichia coli support a model in which
both the leading and lagging strand polymerases are held together in a complex with the …

Publisher Summary DNA polymerase epsilon (Pol epsilon) is a large, multi-subunit
polymerase that is conserved throughout all eukaryotes. In addition to its role as one of the …

Telomere dysfunction arising from mutations in telomerase or in telomere capping proteins
leads to end-to-end chromosome fusions. Paradoxically, the Ku70/80 heterodimer, essential …

Eukaryotic cells distinguish their chromosome ends from accidental DNA double-strand
breaks by packaging them in a protective structure referred to as the telomere “cap.” Here …

Telomeric G‐overhangs are required for the formation of the protective telomere structure
and telomerase action. However, the mechanism controlling G‐overhang generation at …

In Saccharomyces cerevisiae and in humans, the telomerase RNA subunit is bound by Ku, a
ring-shaped protein heterodimer best known for its function in DNA repair. Ku binding to …

The accurate and timely duplication of the genome is a major task for eukaryotic cells. This
process requires the cooperation of multiple factors to ensure the stability of the genetic …

Increasing evidence at the cellular level is helping to provide proximate explanations for the
balance between investment in growth, reproduction and somatic maintenance in wild …

Here we demonstrate that heterogeneous nuclear ribonucleoproteins (hnRNPs) C1 and C2
can associate directly with the integral RNA component of mammalian telomerase. The …