In Saccharomyces cerevisiae, telomere replication occurs in late S phase and is
accompanied by dynamic remodeling of its protein components. Here, we show that MRX …

Almost 400 genes affect yeast telomere length, including Est1, which is critical for
recruitment and activation of telomerase. Here we use mass spectrometry to identify novel …

Telomerase is a telomere dedicated reverse transcriptase that replicates the very ends of
eukaryotic chromosomes. Saccharomyces cerevisiae telomerase consists of TLC1 (the RNA …

The Tbf1 and Reb1 proteins are present in yeast subtelomeric regions. We establish in this
work that they inhibit telomerase‐dependent lengthening of telomere. For example, tethering …

In many somatic human tissues, telomeres shorten progressively because of the DNA-end
replication problem. Consequently, cells cease to proliferate and are maintained in a …

Telomeres, the natural ends of eukaryotic chromosomes, prevent the loss of chromosomal
sequences and preclude their recognition as broken DNA. Telomere length is kept under …

A molecular assessment of checkpoint response can be made by examining the
phosphorylation and kinase activity of the Rad53p kinase, as described by Pellicioli et …

To learn more about the structure of the DNA terminus at Tetrahymena thermophila
telomeres, we have devised a ligation‐mediated primer extension protocol to accurately …

In Saccharomyces cerevisiae, telomeric DNA is protected by a nonnucleosomal protein
complex, tethered by the protein Rap1. Rif and Sir proteins, which interact with Rap1p, are …

Telomeres are complex structures that serve to protect chromosome ends. Here we provide
evidence that in Saccharomyces cerevisiae telomeres may contain an anticheckpoint activity …