Ginsenosides have offered a wide array of beneficial roles in the pharmacological regulation
of hepatic metabolic syndromes, including non-alcoholic steatohepatitis (NASH), non …

DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have
diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase …

Cdc13 is an essential protein from Saccharomyces cerevisiae that caps telomeres by
protecting the C‐rich telomeric DNA strand from degradation and facilitates telomeric DNA …

We envision multiple steps in telomere maintenance, based largely on genetic data from
budding yeast. First, the telomere must unfold or open itself such that the free end is …

Telomerase in Saccharomyces cerevisiae consists of three protein subunits and the RNA
moiety TLC1, which together ensure the complete replication of chromosome ends. TLC1 …

Broken chromosomes healed by de novo addition of a telomere are a major class of
genome rearrangements seen in Saccharomyces cerevisiae and similar to rearrangements …

The Saccharomyces cerevisiae Pif1p helicase is a negative regulator of telomere length that
acts by removing telomerase from chromosome ends. The catalytic subunit of yeast …

In budding yeast (Saccharomyces cerevisiae), the cell cycle-dependent telomere elongation
by telomerase is controlled by the cyclin-dependent kinase 1 (Cdk1). The telomere length …

DNA double-strand breaks (DSBs) are common genome lesions that threaten genome
stability and cell survival. Cells use sophisticated repair machineries to detect and heal …

Abstract [Pd (L)(DMSO) Cl 2](1) and [Pt (L)(DMSO) Cl 2](2) with 9-amino-oxoisoaporphine
(L), were synthesized and characterized. 1 and 2 are more selectively cytotoxic to Hep-G2 …