Saccharomyces telomeres consist of∼ 350 bp of C1-3A/TG1-3 DNA. Most of this∼ 350 bp is
replicated by standard, semiconservative DNA replication. After conventional replication, the …

Gross chromosome rearrangements (GCRs), such as translocations, deletion of a
chromosome arm, interstitial deletions and inversions, are often observed in cancer cells …

Ku is a conserved DNA end-binding protein that plays various roles at different kinds of DNA
ends. At telomeres, Ku is part of the structure that protects the chromosome end, whereas at …

Most normal diploid human cells do not express telomerase activity and are unable to
maintain telomere length with ongoing cell divisions. We show that the length of the single …

In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and
Est3p are thought to form a complex that acts late during chromosome replication (S phase) …

Replicative aging is the process by which most normal human cells “count” the number of
times they have divided, eventually undergoing a growth arrest termed cellular senescence …

Three DNA polymerases are thought to function at the eukaryotic DNA replication fork.
Currently, a coherent model has been derived for the composition and activities of the …

Telomeres are composed of repetitive G-rich sequence and an abundance of associated
proteins that together form a dynamic cap that protects chromosome ends and allows them …

Telomeres are stabilized, and telomeric DNA is replenished, by the action of the
ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the …

In response to DNA damage, cells engage a complex set of events that together comprise
the DNA-damage response (DDR). These events bring about the repair of the damage and …