Background: Genome instability is a hallmark of cancer and plays a critical role in
generating the myriad of phenotypes selected for during tumor progression. However, the …

Telomere has a central role in chromosomal stability events. Chromosome ends organized
in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus …

The response to DNA damage involves regulation of several essential processes to
maximize the accuracy of DNA damage repair and cell survival. Telomerase has the …

Chromatin assembly and DNA replication are temporally coupled, and DNA replication in
the absence of histone synthesis causes inviability. Here we demonstrate that chromatin …

Telomerase, the enzyme that maintains telomeres at natural chromosome ends, should be
repressed at double-strand breaks (DSBs), where neotelomere formation can cause …

Catastrophic losses of telomeric sequences have recently been described during apoptosis,
senescence and tumorigenesis in murine and human cells, in ataxia telangiectasia patients …

The protective caps on chromosome ends–known as telomeres–consist of DNA and
associated proteins that are essential for chromosome integrity. A fundamental part of …

The yeast single-strand TG-repeat telomere binding protein Cdc13 and the telomerase
accessory protein Est1 play essential roles in chromosome end replication. To determine …

The replication of long tracts of telomeric repeats may require specific factors to avoid fork
regression (Fouché, N., Özgür, S., Roy, D., and Griffith, J.(2006) Nucleic Acids Res., in …

Abstract The Saccharomyces cerevisiae Mre11p/Rad50p/Xrs2p (MRX) complex is
evolutionarily conserved and functions in DNA repair and at telomeres [1–3]. In vivo, MRX is …