Mendelian randomization for cardiovascular diseases: principles and applications
SC Larsson, AS Butterworth… - European heart journal, 2023 - academic.oup.com
Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
Mendelian randomization as a tool for cardiovascular research: a review
Importance Mendelian randomization (MR) is a statistical approach that has become
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …
[HTML][HTML] Guidelines for performing Mendelian randomization investigations: update for summer 2023
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
[HTML][HTML] Refining the impact of genetic evidence on clinical success
The cost of drug discovery and development is driven primarily by failure, with only about
10% of clinical programmes eventually receiving approval,–. We previously estimated that …
10% of clinical programmes eventually receiving approval,–. We previously estimated that …
Mendelian randomization analysis of genetic proxies of thiazide diuretics and the reduction of kidney stone risk
JL Triozzi, RS Hsi, G Wang, EA Akwo… - JAMA network …, 2023 - jamanetwork.com
Importance Clinical trial data have called into question the efficacy of thiazide diuretics for
the prevention of kidney stones. Objective To identify whether there is an association …
the prevention of kidney stones. Objective To identify whether there is an association …
[HTML][HTML] MendelianRandomization v0. 9.0: updates to an R package for performing Mendelian randomization analyses using summarized data
The MendelianRandomization package is a software package written for the R software
environment that implements methods for Mendelian randomization based on summarized …
environment that implements methods for Mendelian randomization based on summarized …
[HTML][HTML] The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of …
Background Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness.
This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) …
This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) …
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
Y Chen, G Wang, J Chen, C Wang, X Dong… - Endocrine …, 2024 - academic.oup.com
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …
Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: Application of cis‐multivariable Mendelian randomization to GLP1R gene …
Phenotypic heterogeneity at genomic loci encoding drug targets can be exploited by
multivariable Mendelian randomization to provide insight into the pathways by which …
multivariable Mendelian randomization to provide insight into the pathways by which …
[HTML][HTML] Standardizing the reporting of Mendelian randomization studies
SL Au Yeung, D Gill - BMC medicine, 2023 - Springer
Background Mendelian randomization (MR), ie, instrumental variable analysis using genetic
instruments, is increasingly used in epidemiologic investigations to improve causal …
instruments, is increasingly used in epidemiologic investigations to improve causal …