Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

YAP/TAZ transcriptional co‐activators play pivotal roles in tumorigenesis. In the Hippo
pathway, diverse signals activate the MST‐LATS kinase cascade that leads to YAP/TAZ …

Post-translational modifications (PTMs) are a covalent processing process of proteins after
translation. Proteins are capable of playing their roles only after being modified, so as to …

Abstract Context Prader-Willi syndrome (PWS) is a complex disorder combining
hypothalamic dysfunction, neurodevelopmental delay, hypotonia, and hyperphagia with risk …

The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus
(HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which …

Aim In this review, we have attempted to provide the readers with an updated account of the
role of a family of proteins known as E3 ligases in different aspects of lung cancer …

Background Lupus nephritis (LN) is a common and severe glomerulonephritis that often
occurs as an organ manifestation of systemic lupus erythematosus (SLE). However, the …

The small HERC family currently comprises four members (HERC3–6) involved in the
regulation of various physiological activities. Little is known about the role of HERCs in IFN …

Aims This study aims to find differentially expressed ubiquitination-related gene (s) and
elucidates their biological significance in breast cancer. Main methods Differentially …