Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

Partial agonist activity at the dopamine D2 receptor (DRD2) is a key feature of third-
generation antipsychotics (TGAs). However, TGAs also act as antagonists or weak partial …

In recent decades, much conceptual thinking in trophic ecology has been guided by theories
of nutrient limitation and the flow of elements, such as carbon and nitrogen, within and …

G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into
appropriate cellular responses and mediate the actions of one-third of drugs. GPCR …

G protein–coupled receptors (GPCRs) are important therapeutic targets that exhibit
functional selectivity (biased signaling), in which different ligands or receptor variants elicit …

The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important
drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound …

Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of
chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover …

Abstract Endothelin, a 21-amino-acid peptide, participates in various physiological
processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell …

Several new pairs of active and inactive GPCR structures have recently been solved
enabling detailed structural insight into the activation process, not only of rhodopsin but now …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …