Gout, the most common inflammatory arthritis, is the result of hyperuricemia and
inflammation induced by monosodium urate (MSU) crystal deposition. However, most …

Systemic juvenile idiopathic arthritis (JIA) and adult-onset Still's disease (AOSD) are
systemic inflammatory disorders that manifest as high-spiking fever, joint pain, evanescent …

Increasing evidences indicate that circular RNAs (circRNAs) play important roles in
regulating gene expressions in various diseases. However, the role of circRNAs in …

Abstract Ethnopharmacological relevance Modified Simiaowan (MSM) is a six-herb formula
that has been shown to be effective in gouty arthritis (GA) has been proven, but its regulatory …

Introduction Gout arthritis (GA) is an intermittent inflammatory disease affecting
approximately 10% of the worldwide population. Symptomatic phases (acute flares) are …

Background There is a growing search for therapeutic targets in the treatment of gout. The
present study aimed to evaluate the analgesic and anti-inflammatory potential of angiotensin …

Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals.
HSP60 is a highly conserved stress protein that acts as a cellular “danger” signal for immune …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

Gout is a metabolic disease that seriously affects people's health. Polydatin, a stilbene
compound isolated from Polygonum cuspidatum, has attracted much attention because of its …

Objective To determine the effects of berberine (BBR) on the activation of toll-like receptor 4
(TLR4), nuclear factor (NF) κB (NF-κB) signaling and NLRP3 inflammasome in patients with …