The therapeutic potential of dietary intervention: based on the mechanism of a tryptophan derivative-indole propionic acid on metabolic disorders
Tryptophan (TRP) contributes to individual immune homeostasis and good condition via
three complex metabolism pathways (5-hydroxytryptamine (5-HT), kynurenine (KP), and gut …
three complex metabolism pathways (5-hydroxytryptamine (5-HT), kynurenine (KP), and gut …
Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health
JL Staudinger, A Mahroke, G Patel, C Dattel, S Reddy - Cells, 2024 - mdpi.com
This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by
vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic …
vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic …
Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time
Developmental exposure to the persistent environmental pollutant, polybrominated diphenyl
ethers (PBDEs), is associated with increased diabetes prevalence. The microbial tryptophan …
ethers (PBDEs), is associated with increased diabetes prevalence. The microbial tryptophan …
Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection
S Heumel, V de Rezende Rodovalho, C Urien… - Gut …, 2024 - Taylor & Francis
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV)
infection. In the present study, we used high-resolution shotgun metagenomics and targeted …
infection. In the present study, we used high-resolution shotgun metagenomics and targeted …
Disrupting the gut microbiota/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR/NF-κB pathway in mice
X Cheng, J Chen, X Guo, H Cao, C Zhang, G Hu… - Environmental …, 2024 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer known for its
environmental endocrine-disrupting properties, posing potential risks to various organs …
environmental endocrine-disrupting properties, posing potential risks to various organs …