The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

The impact of systemic inflammation on Alzheimer's disease pathology

J Xie, L Van Hoecke, RE Vandenbroucke - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

Pathogenesis and virulence of herpes simplex virus

S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

SARS‐CoV‐2 targets neurons of 3D human brain organoids

A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency.
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …

Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids

Y Park, CK Franz, H Ryu, H Luan, KY Cotton… - Science …, 2021 - science.org
Three-dimensional (3D), submillimeter-scale constructs of neural cells, known as cortical
spheroids, are of rapidly growing importance in biological research because these systems …

Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3

H Yang, C Oh, H Amal, JS Wishnok, S Lewis… - Science …, 2022 - science.org
Protein S-nitros (yl) ation (SNO) is a posttranslational modification involved in diverse
processes in health and disease and can contribute to synaptic damage in Alzheimer's …

Insights from multi-omics integration in complex disease primary tissues

P Kreitmaier, G Katsoula, E Zeggini - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …

The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

GA De Erausquin, H Snyder, M Carrillo… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction The increasing evidence of SARS‐CoV‐2 impact on the central nervous system
(CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's …

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

R Martínez-Mármol, R Giordano-Santini, E Kaulich… - Science …, 2023 - science.org
Numerous viruses use specialized surface molecules called fusogens to enter host cells.
Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 …

Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …