Next generation strategies for preventing preterm birth

HC Zierden, RL Shapiro, K DeLong, DM Carter… - Advanced drug delivery …, 2021 - Elsevier
Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …

Landscape of preterm birth therapeutics and a path forward

BS Coler, O Shynlova, A Boros-Rausch, S Lye… - Journal of Clinical …, 2021 - mdpi.com
Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50
years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic …

Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled …

MK Hoffman, SS Goudar, BS Kodkany, M Metgud… - The Lancet, 2020 - thelancet.com
Background Preterm birth remains a common cause of neonatal mortality, with a
disproportionately high burden in low-income and middle-income countries. Meta-analyses …

Prospective evaluation of screening performance of first-trimester prediction models for preterm preeclampsia in an Asian population

P Chaemsaithong, RK Pooh, M Zheng, R Ma… - American journal of …, 2019 - Elsevier
Background The administration of aspirin< 16 weeks gestation to women who are at high
risk for preeclampsia has been shown to reduce the rate of preterm preeclampsia by 65 …

Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo …

AJ Landman, MA de Boer, L Visser, TAJ Nijman… - PLoS …, 2022 - journals.plos.org
Background Preterm birth is the leading cause of neonatal morbidity and mortality. The
recurrence rate of spontaneous preterm birth is high, and additional preventive measures …

[HTML][HTML] The role of acetylsalicylic acid in the prevention of pre-Eclampsia, fetal growth restriction, and Preterm birth

J Stubert, B Hinz, R Berger - Deutsches Ärzteblatt International, 2023 - ncbi.nlm.nih.gov
Methods This review is based on pertinent publications that were retrieved by a selective
search in PubMed, with special attention to systematic reviews, meta-analyses, and …

[HTML][HTML] Low-dose aspirin use in pregnancy and the risk of preterm birth: a Swedish register-based cohort study

E Kupka, S Hesselman, R Hastie, R Lomartire… - American journal of …, 2023 - Elsevier
Background Preterm birth is the leading cause of neonatal mortality and morbidity. Women
who have had a previous preterm birth are at increased risk for preterm birth in their …

Risk of preterm birth in relation to history of preterm birth: a population‐based registry study of 213 335 women in Norway

T Tingleff, Å Vikanes, S Räisänen… - … Journal of Obstetrics …, 2022 - Wiley Online Library
Objective To assess the association between preterm first birth and preterm second birth
according to gestational age and to determine the role of placental disorder in recurrent …

New medicines for spontaneous preterm birth prevention and preterm labour management: landscape analysis of the medicine development pipeline

ARA McDougall, R Hastie, M Goldstein, A Tuttle… - BMC Pregnancy and …, 2023 - Springer
Background There are few medicines in clinical use for managing preterm labor or
preventing spontaneous preterm birth from occurring. We previously developed two target …

First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia

PI Cavoretto, A Farina, N Salmeri, A Syngelaki… - American Journal of …, 2024 - Elsevier
Background First-trimester screening for preeclampsia using a combination of maternal risk
factors and mean arterial pressure, uterine artery pulsatility index, and placental growth …