[PDF][PDF] Failure of CD4+ T-cell recovery upon virally-effective cART: an enduring gap in the understanding of HIV+ immunological non-responders

V Bono, M Augello, C Tincati, G Marchetti - New Microbiol, 2022 - newmicrobiologica.org
A unique definition of INR is currently unavailable. Over the years, INRs have generally
been described as subjects who did not reach pre-defined CD4+ lymphocyte counts (ie 200 …

Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV

S Espineira, M Flores-Piñas, S Chafino… - Frontiers in …, 2023 - frontiersin.org
Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual
recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related …

[HTML][HTML] A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

MJ Hole, KK Jørgensen, K Holm, PR Braadland… - Hepatology, 2023 - journals.lww.com
Abbreviations: AC, ascending colon; ALP, alkaline phosphatase; AOM score, Amsterdam–
Oxford model score for PSC; APRI, AST to platelet ratio index; AST, aspartate …

Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals

X Guo, Z Wang, M Qu, Y Guo, M Yu, W Hong, C Zhang… - Msystems, 2023 - Am Soc Microbiol
Although gut microbiota alteration and related blood microbe profiles in human
immunodeficiency virus (HIV)-infected individuals are associated with the disease …

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

C Blázquez-Bondia, M Parera, F Català-Moll… - Frontiers in …, 2022 - frontiersin.org
Background Some HIV-1 infected patients are unable to completely recover normal CD4+ T-
cell (CD4+) counts after achieving HIV-1 suppression with combined Antiretroviral Therapy …

Current knowledge of Th22 cell and IL-22 functions in infectious diseases

K Zhang, L Chen, C Zhu, M Zhang, C Liang - Pathogens, 2023 - mdpi.com
T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their
distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α. Th22 cells …

Comparative transcriptional analysis identified characteristic genes and patterns in HIV-infected immunological non-responders

X Liu, L Lin, L Lu, X Li, Y Han, Z Qiu, X Li, Y Li… - Frontiers in …, 2022 - frontiersin.org
Purpose The incomplete immune reconstitution is a complex phenomenon among human
immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved …

Mucosal‐associated invariant T cells: A cryptic coordinator in HIV‐infected immune reconstitution

B Su, D Kong, X Yang, T Zhang… - Journal of Medical …, 2022 - Wiley Online Library
Human immunodeficiency virus type 1 (HIV‐1) infection causes considerable morbidity and
mortality worldwide. Although antiretroviral therapy (ART) has largely transformed HIV …

[HTML][HTML] Pillars of long-term antiretroviral therapy success

L Taramasso, M Andreoni, A Antinori, A Bandera… - Pharmacological …, 2023 - Elsevier
Background Meeting the challenge of antiretroviral therapy (ART) whose efficacy can last a
lifetime requires continuous updating of the virological, pharmacological, and quality of life …

Severe intestinal barrier damage in HIV-infected immunological non-responders

XY Guo, YT Guo, ZR Wang, YM Jiao, Y Hu, LN Fan… - Heliyon, 2023 - cell.com
The intestinal epithelial barrier plays an important role during human immunodeficiency
virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier …