Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Nitric oxide (NO) is synthesized from l-arginine by NO synthase in virtually all cell types.
Emerging evidence shows that NO regulates the metabolism of glucose, fatty acids and …

Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of the nuclear hormone receptor superfamily. The 3 PPAR isoforms (alpha, delta/beta …

The recognition that nutrients have the ability to interact and modulate molecular
mechanisms underlying an organism's physiological functions has prompted a revolution in …

Peroxisome proliferator-activated receptors (PPARs) compose a family of nuclear receptors
that mediate the effects of lipidic ligands at the transcriptional level. In this review, we …

The ability of pollutants to affect human health is a major concern, justified by the wide
demonstration that reproductive functions are altered by endocrine disrupting chemicals …

Many natural and synthetic compounds present in the environment exert a number of
adverse effects on the exposed organisms, leading to endocrine disruption, for which they …