Automated immunoassays used to evaluate thyroid function are vulnerable to different types
of interference that can affect clinical decisions. This review provides a detailed overview of …

Immunoassays are powerful qualitative and quantitative analytical techniques. Since the first
description of an immunoassay method in 1959, advances have been made in assay …

Thyroid disorders are common, affecting more than 10% of people in the US, and laboratory
tests are integral in the management of these conditions. The repertoire of thyroid tests …

Importance Biotinylated antibodies and analogues, with their strong binding to streptavidin,
are used in many clinical laboratory tests. Excess biotin in blood due to supplemental biotin …

Background Several cases of biotin interference with laboratory testing have been reported
in the literature. However, there are no publications discussing the extent of biotin use or …

Background Laboratory tests that use streptavidin–biotin binding mechanisms have the
potential to be affected by high circulating biotin concentrations, which would produce …

All pathology residents must have a good command of clinical chemistry, toxicology,
immunology, and laboratory statistics to be successful pathologists, as well as to pass the …

Dietary biotin intake does not typically result in blood biotin concentrations that exceed
interference thresholds for in vitro diagnostic tests. However, recent trends of high-dose …

Background Shifts in consumer behavior and clinical practice have increased reports of
biotin interference in immunoassays that incorporate biotin–streptavidin linkages in their …

Thyroid dysfunctions are among the most common endocrine disorders and accurate
biochemical testing is needed to confirm or rule out a diagnosis. Notably, true …