Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Copies: This document is available on the World Wide Web sites of the American College of
Cardiology (http://www. cardiosource. org), the American Association for Thoracic Surgery …

Background Increased life expectancy and younger patients' desire to avoid lifelong
anticoagulation requires a better understanding of bioprosthetic valve failure. This study …

The ideal aortic valve substitute for young and middle-aged adults remains elusive. The
Ross procedure (pulmonary autograft replacement) is the only operation that allows …

Background: Left ventricular (LV) hypertrophy, a key process in human cardiac disease,
results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis) …

Objectives: This study was designed to examine the prognostic value of valvuloarterial
impedance (Zva) in patients with aortic stenosis (AS). Background: We previously showed …

Background: Left ventricular ejection fraction (LVEF) is reduced in a subset of patients with
severe aortic stenosis (AS). Objectives: The authors sought to determine the temporal …

Background—Prosthesis-patient mismatch (P-PtM) after aortic valve replacement results in
disturbed valve performance associated with increased pressure gradients. However, it is …

Calcific aortic stenosis is a progressive disease with no effective medical therapy that
ultimately requires aortic valve replacement (AVR) for severe valve obstruction …

Aims To evaluate myocardial multidirectional strain and strain rate (S-and-SR) in severe
aortic stenosis (AS) patients with preserved left ventricular (LV) ejection fraction (EF), using …