Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Chronic kidney disease (CKD) has emerged as a major cause of morbidity and mortality
worldwide. Interstitial fibrosis, glomerulosclerosis and inflammation play the central role in …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited
regenerative capability in animal models of ischemia–reperfusion (I/R) acute kidney injury …

Sepsis is the major cause of acute kidney injury (AKI) associated with high mortality rates.
Mitochondrial dysfunction contributes to the pathophysiology of septic AKI. Mitophagy is an …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

Acute kidney injury (AKI), defined as a rapid decrease in glomerular filtration rate, is a
common and devastating pathologic condition. AKI is associated with significant morbidity …

Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and
are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in …