The role of oxidative stress in intervertebral disc degeneration

G Cao, S Yang, J Cao, Z Tan, L Wu… - Oxidative medicine …, 2022 - Wiley Online Library
Intervertebral disc degeneration is a very common type of degenerative disease causing
severe socioeconomic impact, as well as a major cause of discogenic low back pain and …

[HTML][HTML] Anti-carcinogenic glucosinolates in cruciferous vegetables and their antagonistic effects on prevention of cancers

P Soundararajan, JS Kim - Molecules, 2018 - mdpi.com
Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …

[HTML][HTML] Cytoplasmic vacuolization in cell death and survival

AV Shubin, IV Demidyuk, AA Komissarov, LM Rafieva… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …

Inflammation and colon cancer

J Terzić, S Grivennikov, E Karin, M Karin - Gastroenterology, 2010 - Elsevier
The connection between inflammation and tumorigenesis is well-established and in the last
decade has received a great deal of supporting evidence from genetic, pharmacological …

Inflammation and colorectal cancer: colitis-associated neoplasia

SI Grivennikov - Seminars in immunopathology, 2013 - Springer
Connection between inflammation and cancer is a rapidly developing field. Epidemiological
data suggests that inflammation along with distinct arms of host immune system plays a very …

[HTML][HTML] The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review

L Li, C Chen, C Chiang, T Xiao, Y Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

[HTML][HTML] B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression

R Wang, Y Ma, S Zhan, G Zhang, L Cao, X Zhang… - Cell death & …, 2020 - nature.com
Tumor angiogenesis is a hallmark of cancer and is involved in the tumorigenesis of solid
tumors. B7-H3, an immune checkpoint molecule, plays critical roles in proliferation …

Targeting matrix metalloproteinases by E3 ubiquitin ligases as a way to regulate the tumor microenvironment for cancer therapy

J Liu, T Chen, S Li, W Liu, P Wang, G Shang - Seminars in cancer biology, 2022 - Elsevier
The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved

S Afrin, F Giampieri, M Gasparrini… - Biotechnology …, 2020 - Elsevier
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of
death. Unfortunately, current medical treatments are not sufficient due to lack of effective …

Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model

Y Gamallat, A Meyiah, ED Kuugbee, AM Hago… - Biomedicine & …, 2016 - Elsevier
Abstract Background/Aim Probiotics have been suggested as prophylactic measure in colon
carcinogenesis. This study aimed at determining the potential prophylactic activity of …